Synergistic, long-term effects of glutamate dehydrogenase 1 deficiency and mild stress on cognitive function and mPFC gene and miRNA expression
Kfir Asraf, Hiba Zaidan, Inna Gaisler-Salomon · FENS Forum 2024
To investigate gene x environment interactions in a mouse model of cognitive deficits, we examined the impact of mild stress in mice genetically modified to express deficient levels of glutamate dehydrogenase 1 (GDH). GDH (gene name: Glud1) plays a central role in glutamate metabolism and is downregulated in the hippocampus of patients with schizophrenia. Mice with a full deletion of Glud1 in CNS (C-Glud1-/- mice) previously showed abnormally high glutamate levels and a wide range of behavioral deficits. Here, we exposed heterozygous C-Glud1+/- mice and their C-Cre+ controls to mild stress in
ePoster · Neuroscience