Alteration of neuron-astrocyte interplay in the early phase of Alzheimer’s disease
Apolline Pierre, Adrien Paumier, Sylvie Boisseau, Quentin Rodriguez, Alain Buisson, Mireille Albrieux · FENS Forum 2024
Alzheimer’s disease (AD) is characterized by a long asymptomatic phase associated with the toxic accumulation of oligomeric form of amyloid-beta peptide (Aβo). One of the first event reported in this phase seems to be a specific hippocampal hyperactivity in both humans and AD mouse model. We highlighted that this early hyperactivity starts with an abnormal increase of calcium activity in astrocytes which affects neighbouring neurons in the hippocampus. We identified an astrocytic calcium channel, transient receptor potential ankyrin-1 (TRPA1), implicated in the Aβo-induced hippocampal hyperact
ePoster · Neuroscience