Embryonic layer 5 pyramidal neurons form earliest recurrent circuits with correlated activity
Arjun Bharioke, Martin Munz, Georg Kosche, Verónica Moreno-Juan, Alexandra Brignall, Alexandra Graff-Meyer, Talia Ulmer, Tiago Rodrigues, Simone Picelli, Cameron Cowan, Botond Roska · COSYNE 2023
Layer 5 pyramidal neurons (L5 PNs) are a major cortical output. Their connectivity approximates a recurrent neural network (RNN), with the majority of inputs coming from other L5 PNs. These neurons may underlie anesthesia-induced unconsciousness, by restricting information output from cortex. Therefore, understanding the formation of the L5 PN circuitry, from the time at which L5 PNs first enter cortex, would provide insight into how a biological RNN can be constructed. However, this is technically challenging because, in mice, L5 PNs first enter cortex at embryonic day (E) 13.5, five days bef
Sat, Mar 11, 2023