PRG-4 (LPPR2) is important for correct protein targeting towards synaptic structures affecting memory and learning
Stefan Wagner, Haichao Ji, Hong Cheng, Sebastian Richers, Heiko Endle, Guilherme Horta, Konstantin Radyushkin, Johannes Vogt · FENS Forum 2024
Plasticity-related genes (PRGs/LPPRs)) belong to a novel subgroup of the lipid phosphate phosphatases family and play a critical role in modulating lysophosphatidic acid signaling in the central nervous system. One characteristic of these proteins is that they tend to come in different combinations and functionally cooperate (Yu, 2015). Here, we sought to explore the role of the poorly characterized PRG-4 comparing wild-type and PRG-4 knockout (PRG4-/-) mice by biochemical and cell biological means, and behavioral tests. Lack of PRG-4 resulted in significantly decreased PRG-1/LPPR4 levels in t
ePoster · Neuroscience