Extending MALAT1 activity to the modulation of LSD1 alternative splicing: A novel cell-autonomous mechanism devoted to neuronal homeostasis
Elena Romito, Chiara Forastieri, Arteda Paplekaj, Andrea De Donato, Sara Testa, Emanuela Toffolo, Elena Battaglioli, Francesco Rusconi · FENS Forum 2024
Numerous long non-coding RNAs (lncRNAs) play pivotal roles in nervous system development and the modulation of neuronal activity, making them crucial physiological players and potential vulnerability points for neuropsychiatric disorders. MALAT1 stands out as one such lncRNA, exerting control over splicing events by sequestering specific SR-family splicing factors in nuclear inactive compartments such as the nuclear speckles, thereby impeding their action on target transcripts. Notably, nSR100, a member of the SR-family, serves as a key splicing regulator, facilitating the generation of neuroL
ePoster · Neuroscience