Serotonergic neurons in the dorsal raphe regulate visual attention
Jonas Lehnert, Xinyue Ma, Anmar Khadra, Kuwook Cha, Julia Forestell, Kerry Yang, Jonathan Britt, Arjun Krishnaswamy, Erik Cook · COSYNE 2025
Visual attention enhances the neural representation of salient stimuli within the visual cortex. Although it is generally thought that this enhancement is driven by glutamatergic feedback from frontal cortical areas, cortically released neuromodulators are also believed to play a major uncharacterized role. Here we report the unexpected observation that dorsal raphe (DR) derived serotonin (5HT) controls visual attention. We adopted a behavioral model that captured how mice allocated attention to cued and uncued visual features. Simultaneous photometry recordings showed that DR activity decreas
ePoster · Neuroscience