Unraveling glutamatergic dysregulation in RARβ null mice striatal synapses and its implications in neurological disorders
Hanna Semaan, Jean-Marc Strub, Christine Schaeffer-Reiss, Wojciech Krezel · FENS Forum 2024
The intricate tapestry of the brain relies on a complex web of signaling pathways among its neurons. At the heart of this neural symphony is glutamatergic signaling.Glutamatergic control of striatal activity is essential for several brain functions.Abnormal glutamatergic signaling is associated with several pathological conditions including Huntington’s disease (HD), a rare neurological disease marked by striatal dysfunction and degeneration.Compromised retinoic acid receptor beta (RARβ) signaling observed in the striatum of HD patients and mice models has been suggested to critically contribu
ePoster · Neuroscience