Examining the transcriptomic signature of the thalamus in a dual-hit rat model of schizophrenia: Insights into gender-specific alterations
Blanca Sánchez-Moreno, Ángela Calzado-González, Ana Isabel Fraga-Sánchez, Inés García-Ortiz, Miriam Martínez-Jiménez, Claudio Toma, David Vega-Avelaira, Javier Gilabert-Juan · FENS Forum 2024
Aims: This study aims to elucidate the transcriptomic changes underlying thalamic alterations in an animal model of schizophrenia. Methods: We used a 'dual hit' rat model of schizophrenia, which combines an injection of non-competitive NMDA receptor antagonist MK-801 at P7 and 8 weeks of postweaning social isolation. The model was developed in both male and female rats. At 3 months, behavioral tests and RNA sequencing (RNAseq) of the thalamus were performed. Differential expressed genes (DEGs) and enriched categories were validated in silico via MAGMA using GWAS summary statistics of the Psych
ePoster · Neuroscience