Subcellular localization of GlyRα2 in spiny projection neurons
Yana Vella, Piccart Elisabeth, Serge N Schiffmann, Jean-Michel Rigo, Jelle Hendrix, Bert Brône · FENS Forum 2024
The glycine receptor alpha 2 (GlyRα2) is the only functionally expressed glycine receptor in adult striatal projection neurons (SPNs) and an important modulator of signal integration within the dorsal striatum. SPNs are a convergence point for glutamatergic and dopaminergic input, which is key to reward-motivated behavior. Thus, targeting GlyRα2 offers great potential to modulate striatum-orchestrated behavior. However, the impact of GlyRα2's subcellular localization on SPN activity regulation remains unclear.Neurons are morphologically complex cells, containing many subcellular compartments (
ePoster · Neuroscience