Topic: glycinergic inhibition

Orientation is one of the most salient features in visual scenes. Neurons at multiple levels of the visual system detect orientation, but in many cases the underlying biophysical mechanisms remain unresolved. Here, we study the mechanism for orientation detection at the earliest stage in the visual system, in B/K wide-field amacrine cells (B/K WACs), a novel group of giant, non-spiking interneurons in the mouse retina. B/K WACs exhibit orientation-selective calcium signals along their long, straight, unbranching dendrites, which contain both synaptic inputs and outputs. In this study, we ident