Distribution of rodent cerebellar glycogen and its role in motor behavior
Ashley Bomin Lee, Sonam Akther, Ayumu Konno, Antonios Asiminas, Marta Vittani, Tsuneko Mishima, Hirokazu Hirai, Claire Meehan, Jordi Duran, Joan Guinovart, Hitoshi Ashida, Tsuyoshi Morita, Otto Baba, Ryuichi Shigemoto, Maiken Nedergaard, Hajime Hirase · FENS Forum 2024
The mammalian brain stores glucose, the main energy substrate from the blood circulation, in the form of glycogen. In the rodent brain, the cerebellum stores relatively large amounts of glycogen, yet the cellular and subcellular distribution of glycogen has not been described in detail. Using monoclonal antibodies against glycogen, we investigated the glycogen distribution in the mouse cerebellar cortex. We found a dominant presence of glycogen in molecular layer Bergmann glia (BG) processes. Additionally, glycogen was observed in Purkinje cells (PCs), the principal neurons of the cerebellar c
ePoster · Neuroscience