Topic: GlyT1 inhibitor

Working memory is the ability to hold and handle information for a limited time in order to use previously garnered information. It plays an important role in day-to-day life and is impaired in several neuropsychiatric disorders such as schizophrenia and bipolar disorder. In mice, working memory can be assessed in both, mazes (e.g., water-maze or T-maze) and operant boxes. One of the tasks developed for touchscreen operant boxes is the trial unique non-matched to location (TUNL) task. Although much literature is available showing pharmacological reduction of working memory on this task, the nu