Subclass-specific impact of ether lipid deficiency on mouse brain pathology and behaviour
Johannes Berger, Charlotte Brecx, Erik Harrucksteiner, Maurice Besch, Christian Pifl, Petra Scholze, Sylvia Badurek, Artur Vansimpsen, Sonja Forss-Petter, Katrin Watschinger, Fabian Dorninger · FENS Forum 2024
Ether phospholipid synthesis has been genetically and physiologically linked to neurodevelopmental diseases like ADHD and autism. However, so far it is unclear whether plasmalogen or non-plasmalogen ether lipid species mediate this association. To address this, we compared two distinct mouse models, namely Gnpat KO and Peds1 KO, and wild-type controls. Glyceronephosphate O-acyltransferase (GNPAT) initiates the formation of the defining ether bond inside peroxisomes; lack of this enzyme abolishes the biosynthesis of all ether lipids. Plasmanylethanolamine desaturase (PEDS1, TMEM189) completes p
ePoster · Neuroscience