Sex and age modulate gene expression of epigenetic and estradiol signaling in the mouse trigeminal ganglion
Álvaro Bautista-Abad de la Cruz, Nuria García Magro, Julia Simon-Areces, Luis Miguel Garcia Segura, Maria-Angeles Arevalo, Pilar Negredo Madrigal, Daniela Grassi · FENS Forum 2024
Biological sex, gonadal hormones, and the epigenetic landscape collectively influence pain sensitivity, contributing to sex-based differences in pain perception. Females typically display heightened sensitivity to noxious stimuli, with estradiol's impact on hyperalgesia. Estradiol functions as a hormone released by peripheral steroidogenic organs or as neuroestradiol, locally synthesized in the nervous system by aromatase, which plays a crucial role in regulating neuroestradiol levels in pain circuits. This study investigates the role of neuroestradiol and its epigenetic involvement in the tri
ePoster · Neuroscience