Glycine modulates the excitability of medium spiny neurons in the nucleus accumbens through GPR158 activation
Marcello D'Ascenzo, Giuseppa Aceto, Luca Nardella, Simona Nanni, Valeria Pecci, Alessia Bertozzi, Sofia Nutarelli, Maria Teresa Viscomi, Claudia Colussi, Claudio Grassi · FENS Forum 2024
GPR158, a class C orphan G protein-coupled receptor, has been shown to function as a metabotropic glycine receptor. The nucleus accumbens (NAc), a significant basal ganglia component that integrates data from cortical and subcortical structures to drive goal-directed behaviors, exhibits high levels of GPR158 expression. It is unknown, however, how GPR158 activation affects the NAc's neuronal activity. Using whole-cell patch-clamp recordings we found that glycine-dependent activation of GPR158 elevates evoked firing of NAc medium spiny neurons (MSNs), while activation of GPR158 in cholinergic i
ePoster · Neuroscience