A specific GPR56/ADGRG1 splicing isoform is associated with suicidal behavior and antidepressant response in major depressive disorder
Montaine Lion, El Chérif Ibrahim, Raoul Belzeaux, Eleni Tzavara · FENS Forum 2024
Major depressive disorder (MDD) is one of the most common psychiatric disorders. Very difficult to treat, this disease is one of the leading causes of suicide. A recent study showed an association between GPR56/ADGRG1 mRNA, MDD and response to antidepressant treatment in blood and in brain. Among GPR56 transcript isoforms, the S4 isoform has recently been associated with microglial synaptic pruning, while microglia are already known as a central player in MDD. Therefore, we hypothesize that S4 is the specific isoform associated with MDD and antidepressant response. To test our hypothesis, an i
ePoster · Neuroscience