Topic: Gq signaling

Electrical activity plays a crucial role in the development of neurons and the formation of neuronal networks. Designer receptors exclusively activated by designer drugs (DREADDs) are chemogenetic tools that can control the activity of neurons at the single-cell level by activating specific G protein signaling. In this study, we aimed to investigate whether the excitatory hM3Dq receptor is sufficient to influence the growth of dendrites and axons in cortical neurons. When activated, Gq-coupled hM3Dq leads to depolarization by increasing intracellular calcium levels. We biolistically transfecte