Chronic in vivo two-photon imaging of cortical noradrenaline reveals altered spatiotemporal release dynamics during motor learning in a mouse model of autism
Nathaniel Jones, Simon Chen · FENS Forum 2024
Noradrenaline (NA) is a strong modulator of neuronal activity and many autism spectrum disorder (ASD) symptoms can be attributed to maladaptive activity of locus coeruleus (LC), the main source of forebrain NA. Our lab recently uncovered a role for dysregulated LC-NA function in motor learning delays of the 16p11.2 deletion (+/-) mouse-model of ASD. We found that reduced NA levels in primary motor cortex (M1) caused delays in motor learning and increased neuronal activity in M1 pyramidal neurons. Both behavioral and neuronal phenotypes were rescued by chemogenetic activation of LC-NA. We next
ePoster · Neuroscience