A sandwich of glioblastoma cells and a brain tissue slice: An in vitro model to explore interactions of tumour cells with neural tissue
Maurice Meseke, Benjamin Schwindenhammer, Hamber Ahmad Alissa, Igor Jakovcevski, Ramon Rebstock, Eckart Förster · FENS Forum 2024
Glioblastoma (GBM) is a frequent, treatment resistant adult brain tumour which is classified as a grade IV glioma (Louis et al., 2016). To date treatment options for glioblastoma brain tumours are limited and no reliable markers are available to distinguish migratory active from resting glioblastoma cells. Here, we investigated the rat glioblastoma cell line C6 and their invasive behaviour on living brain tissue, represented by rat hippocampal slice cultures. We established a model system where brain tissue (represented by organotypic slice cultures) is overlayed with fluorescently labelled gl
ePoster · Neuroscience