Functional upregulation of KCC2 in cortical interneurons precedes that in glutamatergic principal neurons
Rakenduvadhana Srinivasan, Geneviève Chazal, Elina Nagaeva, Juzoh Umemori, Pavel Uvarov, Sari Lauri, Anastasia Ludwig, Claudio Rivera · FENS Forum 2024
GABAergic interneurons (INs) and their maturation play a pivotal role in various brain functions, with implications for a wide spectrum of neurological and psychiatric disorders. Among the key regulators of GABAergic inhibition, the cation chloride co-transporter KCC2 is central; influencing interneuronal function, CNS development, plasticity, and disease pathology. While KCC2's role in principal neurons’ transition of GABAergic signaling from depolarizing to hyperpolarizing is well-documented, its expression patterns and functional significance in interneurons, particularly during early neona
ePoster · Neuroscience