Nanometer-scale dendritic shaft constrictions shape dendritic integration and plasticity
Tony Kelly, Michela Barboni, Michael Döng, Juan Eduardo Rodriguez-Gatica, Carlos Wert-Carvajal, Philipp Bethge, Michel Herde, Schweihoff Jens, Martin Schwarz, Ulrich Kubitscheck, Valentin Nägerl, Tatjana Tchumatchenko, Heinz Beck · FENS Forum 2024
Dendrites are the main input structures of neurons, receiving and integrating thousands of excitatory synaptic inputs. Compartmentalisation is a key feature of dendrites with the intricate structure of spine necks creating single synapse electrical and chemical compartments. However, the morphological features compartmentalising along single branches are less well understood.Using super-resolution techniques (Stimulated Emission Depletion Microscopy and expansion microscopy) of granule cell dendrites, we observed localized reductions in the dendritic shaft diameter to values below 300 nm that
ePoster · Neuroscience