Semantic memories are not generated from multiple episodic memories
Anumita Samanta, Jonna Spellmeyer, Liz van der Brand, Laura Olmedo Martinez, Adrian Aleman-Zapata, Alejandra Alonso, Irene Navarro-Lobato, Lisa Genzel · FENS Forum 2024
Fact knowledge – known as semantic memories – is proposed to be derived from individual memories of events during a memory consolidation period after learning. But so far, this has never been shown. Here, we tracked gene expression in a 2-week semantic-like memory paradigm in mice across the whole-brain spatial memory network. Absolute gene expression was driven by first experiences and later learning led to smaller changes, highlighting that multiple episodic memories are not encoded and then consolidated to create semantic-memories, instead already by the second experience semantic-memories