Topic: grid cell code

Understanding how the brain builds maps of novel environments on behavioral timescales (seconds-minutes) is a fundamental question for neuroscience. Theoretical works posit a Hebbian plasticity mechanism for integrating novel landmarks [1]. Drosophila have been shown to use such a mechanism to integrate novel landmarks on timescales of minutes [2,3]. However, current evidence suggests that plasticity in the medial entorhinal cortex (MEC) operates on the timescale of days [4] — leaving open the question of how the mammalian brain maps novel environments on behavioral timescales. Here we investi