Topic: GRIN1-G620R

GRIN disorders are rare neurodevelopmental disorders caused by pathogenic variants in the GRIN genes that encode the N-methyl-D-aspartate receptor (NMDAR) subunits. Two such missense variants of the GluN1 subunit, GRIN1-G620R and GRIN1-G827R, have been identified in multiple patients with profound intellectual disability and developmental delay. To understand the nature of the NMDAR deficits imparted by these variants, we generated Grin1 G620R and G827R mouse models that mimic the heterozygous condition found in affected individuals. Synaptic function was assessed using electrophysiological re