Myelin plasticity requires the expression in oligodendrocyte progenitors of NMDA receptors containing GluN3A subunits
Moumita Chatterjee, Alice Staffa, Ana Isabel Navarro Navarro, Ariadna Diaz-Tahoces, Carlos Parras, J. C. Chara Ventura, Carlos Matute, Isabel Perez Otano · FENS Forum 2024
Work over the last decade demonstrates that the myelin sheaths enwrapping axons, classically seen as static insulators, are highly dynamic and respond to axonal activity and experience. This phenomenon, called “myelin plasticity”, goes beyond postnatal stages into adulthood and plays a key role in remodeling neuronal circuits to support adaptive behavior or functional recovery upon injury. Yet the mechanisms are unknown. Here we show that NMDA receptors containing GluN3A subunits are expressed by oligodendrocyte progenitor cells (OPCs) and essentially required for activity-dependent myelin pla
ePoster · Neuroscience