Topic: Grip test

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by motor neuron death, leading to motor paralysis and cognitive and behavioural disorders. In clinical trials, ALS patients are stratified by disease stage, whereas in preclinical studies, animals are recruited based solely on age, neglecting individual disease progression. Additionally, both ALS onset and progression are influenced by sex, a factor often mirrored in animal models. This mismatch might contribute to the frequent failures of translating preclinical data to clinical success, suggesting the impo