Topic: Grn-deficient mice

Progranulin (PGRN), encoded by the GRN gene, is a potent neurotrophic and anti-inflammatory factor expressed by neurons and microglia. Heterozygous or homozygous loss-of-function mutations in the human GRN gene cause frontotemporal dementia and neuronal ceroid lipofuscinosis, respectively. Previous studies also demonstrated exacerbated consequences in Grn-deficient mice after experimental traumatic brain injury (TBI). However, the relative contribution of neuronal or microglial PGRN in neuroprotective and anti-inflammatory effects is still elusive. Here, we tested the hypothesis that transgeni