Nanobody-based FRET biosensors to quantify endogenous group I metabotropic glutamate receptors
Ugo Alenda, Pierre-André Lafon, Damien Meyer, Patrick Chames, Véronique Perrier, Philippe Rondard · FENS Forum 2024
G protein-coupled receptors (GPCR) are the largest family of membrane proteins in the human genome and represent targets of about 30% of the marketed drugs. Among GPCRs, metabotropic glutamate receptors (mGluRs) are interesting targets as they regulate neuronal excitability and synaptic transmission in the central nervous system, and are involved in various brain diseases. Due to the lack of specific tools, their specific subunit composition in native tissues is still difficult to determine. Finding highly specific tools to target each mGluR subunit is still a challenge that single domain anti
ePoster · Neuroscience