Topic: growth cone retraction

Neural network formation throughout development and regeneration after injury depends on accuracy of axonal pathfinding, which is influenced by chemical and physical cues. Recently, there is growing evidence that local temperature fluctuations in the brain play a crucial role in axonal guidance. However, the precise mechanisms involved in this process are not completely understood. We hypothesize that spontaneous and trauma-induced axon growth is repelled by increasing nanoscale temperature gradients leading to growth inhibition and growth cone retraction. Transient receptor potential vanilloi