Topic: growth cones

Axonal protein synthesis seems to play an important role in retinal ganglion cells (RGCs) axon guidance because axonal mRNAs could be locally translated “on demand” during axonal navigation. During embryonic development, RGC axons project to the brain and have to decide whether or not to cross the midline at the level of the optic chiasm. There are two types of RGCs, the contralateral ones (cRGCs) that respond to attractive cues; and the ipsilateral ones (iRGCs), that respond to repulsive cues. Although RGCs growth cones have a very fast dynamic behavior in response to environmental stimuli, k