Topic: guidepost cells

The proper formation of neural circuits depends on the precise pathfinding of axons, which is mediated by various molecules. While the expression of specific guidance molecules by different cells in the nervous system has been well characterized, the mechanisms underlying the secretion and delivery of these molecules to growing axons remain relatively unexplored.In this study, we used ex vivo live imaging techniques to investigate the guidance of commissural axons in the chicken embryo. Our findings reveal that multiple populations of guidepost cells employ long filopodia, known as cytonemes,