Increased intestinal permeability and unexpected resilience to DSS colitis-induced sickness behaviour in the Neuroligin-3R451C mouse model of autism
Samantha Matta, Chalystha Lee, Vic Lin, Yuansong Li, Joshua Williams, Suzanne Hosie, Mohammed Alamoudi, Anya Shindler, Jennifer Wood, Peter Crack, Ashley Franks, Elisa Hill · FENS Forum 2024
Individuals with autism spectrum disorder (ASD; autism) are more susceptible to inflammatory disorders and gastrointestinal dysfunction, but the cause is unknown. We investigated gut permeability and the impact of acute inflammatory insult on gut function and behaviour in Nlgn3R451C mice expressing an autism-associated mutation in Neuroligin-3. Ex vivo intestinal permeability was assessed by measuring the passage of FITC across the mucosa from the lumen. To compare impacts of modulating the nervous system with immune pathway disruption, we bred Nlgn3R451C mice with mice lacking the interferon
ePoster · Neuroscience