Epigenomic profiling of Alzheimer’s and Pick’s disease at the single-nucleus level
Zechuan Shi, Sudeshna Das, Samuel Morabito, Emily Miyoshi, Jennifer Stocksdale, Shushrruth Sai Srinivasan, Arshi Shahin, Jing Zhang, Elizabeth Head, Leslie Thompson, Vivek Swarup · FENS Forum 2024
Neurodegenerative disorders, including Alzheimer's disease (AD) and Pick's disease (PiD), are characterized by the accumulation of tau-positive inclusions within neurons or glial cells. These tauopathies exhibit distinct tau isoform profiles, with primary tauopathies such as PiD predominantly featuring 3R tau, while secondary tauopathies like AD involve both 3R and 4R isoforms. Recent scientific investigations have uncovered the impact of tau alterations, including overexpression and hyperphosphorylation, on chromatin structure. In this study, we present a comprehensive analysis of epigenomic
ePoster · Neuroscience