Characterization of multi-target ligands comprising opioid/non-opioid pharmacophores for the treatment of pain
Emile Breault, Jolien De Neve, Santo Previti, Esaü Vangeloven, Rebecca Brouillette, Magali Chartier, Brian Holleran, Émilie Eiselt, Frédérique Lussier, Annik Lanoie, Jean-Michel Longpré, Louis Gendron, Steven Ballet, Philippe Sarret · FENS Forum 2024
The management of chronic pain remains one of the greatest challenges of the 21st century, affecting over a third of the world’s population, and yet it is often not treated appropriately. To address this important public health issue, dual-target ligands that can engage more than one receptor and exert complementary analgesic actions represent a promising avenue for the treatment of acute and chronic pain. Therefore, ligands acting on the neurotensin receptor type 2 (NTSR2), which exert non-opioid antinociceptive effects and a synergistic effect when co-administered with opioids, offer an attr
ePoster · Neuroscience