Topic: H2AK119ub

During mammalian neurodevelopment, the establishment of spatial and temporally appropriate gene expression programmes ensures the correct production of distinct neural and glial cell types. This process is partially regulated by the modification of chromatin structure by epigenetic complexes, including the Polycomb group (PcG) family of co-repressors. Genetic screening has identified several PcG mutations that are causally associated with a range of congenital brain disorders, yet the specific regulatory roles of Polycomb complexes during normal neurodevelopment is still unclear. Here, we inve