Lesions of the lateral hypothalamus-nigral projection result in motor deficits in rats: Implications for Parkinson’s disease
Asena Bingul, Sam Merlin, Simon Killcross, Teri Furlong · FENS Forum 2024
The lateral hypothalamus (LH) is emerging as a brain region of interest in Parkinson’s disease (PD). Specifically, the LH neuron populations have been shown to degenerate in PD, thus undergoing neuron loss like the substantia nigra (SN) which is a defining feature of PD that is thought to underlie observed motor symptoms. Interestingly, the LH has strong anatomical projections to the SN, but the behavioural functions associated with this projection have not been determined. We have recently shown that the LH is involved in habitual instrumental responding and spontaneous locomotor activity in
ePoster · Neuroscience