A pH-sensitive closed-loop nanomachine to control hyperexcitability at the single neuron level
Caterina Michetti, Assunta Merolla, Matteo Moschetta, Francesca Vacca, Lorenzo Ciano, Federica Spada, Laura Emionite, Simonetta Astigiano, Fabrizia Cesca, Elisabetta Colombo, Fabio Benfenati · FENS Forum 2024
Epilepsy is a frequent neurological disorder affecting about 1% of the general population, with 30% of patients that are resistant to antiepileptic drugs. In the last decade, optogenetics has emerged as an efficient antiepileptic strategy, although the difficulty of illuminating multiple and deep areas of the brain still poses translational challenges. In this scenario, the search of alternative light sources is strongly needed. Here, we developed a closed-loop chemo-optogenetic nanomachine, named pH-sensitive inhibitory luminopsin (pHIL), composed of a luciferase-based light generator, a fluo
ePoster · Neuroscience