Topic: HCN knockout

Hyperpolarization-activated cyclic nucleotide-gated (HCN) channel is thought to play a key role in the modulation of dendritic and somatic excitability in neurons [1]. The enigmatic HCN channel, enigmatic because of the long puzzling relation between HCN expression and neural function [1, 2, 3], has an inhomogeneous distribution along the somato-dendritic axis, where the density is higher in distal dendritic compartments [1, 4]. In this modeling project, we studied the influence of HCN channel density distribution on the attenuation of current injection from the bifurcation point of the dendri