Topic: HDAC inhibitors

In the past decade, an increasing number of studies have been focusing on identifying Alzheimer’s disease (AD)-related epigenetic modifications, both in humans and mouse models. Recently, it has been shown that late-stage AD human samples show alterations in histone modifications, chromatin compartmentalisation, and chromatin structural protein localisation (Xiong et al., Cell, 2023). These changes collectively result in epigenome erosion. However, the mechanisms and the role of chromatin structural proteins underpinning this event remain unclear. Likewise, it remains uncertain whether cogniti