Topic: head-direction cells

When animals navigate on a two-dimensional (2D) surface, many neurons in the medial entorhinal cortex (MEC) are activated as the animal passes through multiple locations (‘firing fields’) arranged in a hexagonal lattice that tiles the locomotion-surface; these neurons are known as grid cells. However, although our world is three-dimensional (3D), the 3D volumetric representation in MEC remains unknown. Here we recorded MEC cells in freely-flying bats and found several classes of spatial neurons, including 3D border cells, 3D head-direction cells, and neurons with multiple 3D firing-fields. Man

Rodents and primates exhibit trade-offs between exploitation and exploration. Understanding how different behavioral states modulate neural activities remains a critical question. Previous research has demonstrated that high and low head pitch in rats correlate with distinct head-movement frequencies, which are coupled with breathing frequency, suggesting a potential connection between pitch states and exploration/exploitation behaviors. Additionally, place cells exhibit remapping across low/high-pitch states. In our study using a path-integration paradigm with rats, we found that parameters