A cortico-collicular circuit for accurate orientation to shelter during escape
Dario Campagner,Ruben Vale,Panagiota Iordanidou,Oriol Pavon Arocas,Yu Lin Tan,Federico Claudi,Anna Vanessa Stempel,Sepiedeh Keshavarzi,Rasmus Strange Petersen,Troy Margrie,Tiago Branco · COSYNE 2022
Escaping towards shelter is an adaptive behaviour offering protection against predation. In mice, this is preceded by a fast, memory-guided head rotation towards the shelter[1]. It is not known how the escape circuit incorporates spatial information to execute rapid and accurate flights to safety. Here we show that retrosplenial cortex (RSP) and superior colliculus (SC) form a monosynaptic circuit that continuously encodes shelter direction and is necessary for spatially-accurate escape. Using Neuropixels probes, we found head-shelter angle cells (HSAC) in RSP and SC. Both multivariate tuning
Thu, Mar 17, 2022