Topic: head-twitching

Several drugs of abuse have recently been shown clinically to have long-lasting antidepressant effects. Psilocybin and ketamine induce antidepressant effects which last for days or weeks after a single dose, yet their pharmacology is distinct. Psilocybin is a classical psychedelic which acts via 5-HT2A receptor agonism, and ketamine is a NMDA receptor antagonist with dissociative hallucinatory properties. Our goal was to increase our understanding of acute drug effects in mice. We treated wildtype mice with psilocybin (1 mg/kg, i.p.) or ketamine (30 mg/kg, i.p.) and analyzed their behavior in