Blood pressure pulsations modulate olfactory bulb activity via mechanosensitive ion channels
Luna Jammal Salameh, Sebastian H. Bitzenhofer, Ileana L. Hanganu-Opatz, Mathias Dutschmann, Veronica Egger · FENS Forum 2024
(Jammal Salameh et al., Science_2024)Heartbeat transmission through the cerebral vascular system is known to cause intracranial pressure pulsations. Here we show for the first time that arterial pressure pulsations can directly modulate neuronal activity within the central nervous system via baroreceptive transduction. We recorded local-field-potentials (LFP) within the rat olfactory bulb (OB) using a semi-intact, perfused nose-brain preparation, while monitoring the pressure pulsations induced by the peristaltic perfusion pump that in our setup operated within the physiological range of hea
ePoster · Neuroscience