Topic: Hebbian-weight amplification

One of key hallmarks of cognitive flexibility is the capability of quickly performing neural computation to accommodate dynamic, context-switching environments and deal with task uncertainty [1-3]. Accumulating evidence from human and animal experiments have suggested that the mediodorsal (MD) thalamus and prefrontal cortex (PFC) are a pair of critical partners to achieve cognitive control. e found that such multiplicative thalamocortical gating enables a local Hebbian-weight amplification for prefrontal synaptic plasticity and is the key to facilitate a low-rank structure in prefrontal comput