Topic: Hedonic overeating

Hedonic overeating is usually derived from overriding homeostatic food intake (FI) and is thought to be mainly responsible for modern age obesity. Glucagon-like peptide 1 (GLP-1) is a major signal of reaching energy balance and satiety, having a major role in normal FI behaviour.We investigated the effects of the GLP-1 agonist exenatide on palatability-driven feeding regulation in adult male rhesus macaques (n=5) using a novel operant FI paradigm. In each session, one of two available food pellets with different palatability values was offered as meal in all combinations with two daily feeding