Investigation of GABA transport and the GABA/Na+ relationship in human GAT1 using solid-supported membrane-based electrophysiology
Rocco Zerlotti, Elena Dragicevic, Maria Barthmes, Andre Bazzone · FENS Forum 2024
The neurotransmitter γ-aminobutyric acid (GABA) plays a pivotal role as the primary inhibitory neurotransmitter in the brain, and its regulation primarily relies on the activity of the GABA transporter hGAT1 within the central nervous system (CNS). hGAT1 is classified as a secondary-active transport protein, utilizing the sodium ion (Na+) gradient to power the transport of GABA from the synaptic cleft back into the presynaptic neuron. Given its association with numerous neurological disorders, dysregulation in GABA transport underscores the significance of hGAT1 as a therapeutic target. Solid-
ePoster · Neuroscience