Improving neuroprotection against a nerve agent exposure with the association of two oximes
Alexandre Champault, Madelyne Jego, Rosalie Bel, Assia Belkebir, Julie Knoertzer, Marilène Trancart, Anne-Sophie Hanak, André-Guilhem Calas, Armelle Rancillac, Grégory Dal Bo, Karine Thibault · FENS Forum 2024
Organophosphate (OP) nerve agent (NA) like VX are irreversible acetylcholinesterase (AChE) inhibitors. Acute NA exposure leads to a cholinergic syndrome, due to acetylcholine accumulation in synapses, manifested by fasciculation, tremors, muscle paralysis and a respiratory distress leading to death. Antidote treatment includes a muscarinic cholinergic receptor antagonist (atropine) and an oxime able to reactivate OP-inhibited AChE. In central nervous system, oximes action is limited due to their weak ability to cross the blood brain barrier (BBB). The goal of this study was to test therapeutic
ePoster · Neuroscience