Interactions between amyloid beta 1-42 and nuclear transcription factors in mitochondria
Zuhal Yurttaş, Tugay Çamoğlu, Erdinç Dursun, Duygu Gezen Ak · FENS Forum 2024
Amyloid beta1-42(Aβ1-42) peptide, a major pathological component of Alzheimer's disease(AD), is known to locate and accumulate in the mitochondria.Research has demonstrated that nuclear transcription factors(nTF) play a direct or indirect role in the transcriptional regulation of mitochondria, which lose function in the early stages of neurodegenerative diseases.Based on this information, our study investigates the interactions between Aβ and nTFs in mitochondria.In this study, the interaction of 48 nTFs with Aβ was examined using a nTF-interaction kit. Mitochondrial lysate isolations were per
ePoster · Neuroscience