Impact of type 2 diabetes and high-intensity interval exercise on neurogenesis, angiogenesis, and the accumulation of lipid droplets in the hippocampus
Harald Stranger Mjønes, Gezime Seferi, Mona Havik, Cecilie Morland · FENS Forum 2024
The risk of developing Alzheimer’s disease (AD) is doubled in individuals with type 2 diabetes (T2D). While the prevalence of both diseases increases globally, the T2D-AD link remains to be elucidated. Ectopic accumulation of lipids (lipotoxicity) is a known consequence of T2D and has lately been suggested as a driver for AD. Angiogenesis and adult neurogenesis are thought to be affected in both diseases. Physical exercise acts preventively against AD and T2D and has been shown to stimulate angiogenesis and neurogenesis. In this study, we exposed animals from the db/db mouse model of T2D to ei
ePoster · Neuroscience