Topic: high-throughput drug discovery

Amyotrophic Lateral Sclerosis (ALS), is a neurodegenerative disorder characterised by the progressive and rapid loss of upper and lower motor neurons within the central nervous system. ALS exhibits significant heterogeneity, demonstrating variability in clinical presentation, disease progression, and the neural populations affected. This diversity has historically complicated identifying disease mechanisms and devising universally effective treatments. Organoids derived from patient pluripotent stem cells offer an innovative platform to investigate ALS, by recapitulating the multicellular comp